Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

348
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
348
Bacterial Flora of the Large Intestine01:29

Bacterial Flora of the Large Intestine

500
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
500
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

200
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
200
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

304
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
304
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

225
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
225
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

164
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
164

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laparoscopic low anterior resection with en bloc total hysterectomy and bilateral salpingectomy for stage IV endometriosis-A video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2026
Same author

Pediatric vs Adult Colonoscopes' Effectiveness in Obese Patients: The PACE Randomized Clinical Trial.

The American journal of gastroenterology·2026
Same author

Corrigendum to 'High-Definition Intravascular Ultrasound Versus Optical Coherence Tomography: Lumen Size and Plaque Morphology' [Journal of the Society for Cardiovascular Angiography & Interventions; 4 (2025) 102520].

Journal of the Society for Cardiovascular Angiography & Interventions·2025
Same author

Computational simulations of coronary artery bifurcation stenting using realistic plaque distribution and materials.

Scientific reports·2025
Same author

High-Definition Intravascular Ultrasound Versus Optical Coherence Tomography: Lumen Size and Plaque Morphology.

Journal of the Society for Cardiovascular Angiography & Interventions·2025
Same author

Impact of frailty on outcomes and biliary drainage strategies in acute cholangitis: A retrospective cohort analysis.

Clinics and research in hepatology and gastroenterology·2025
Same journal

Endoscopic techniques to minimize gastroesophageal reflux during peroral endoscopic myotomy.

Current opinion in gastroenterology·2026
Same journal

Postendoscopy esophageal adenocarcinoma and neoplasia: current status and future directions.

Current opinion in gastroenterology·2026
Same journal

The complement system in inflammatory bowel disease: from early observations to emerging frontiers.

Current opinion in gastroenterology·2026
Same journal

Goblet cell-associated antigen passages in health and disease.

Current opinion in gastroenterology·2026
Same journal

Inflammatory bowel diseases 2026: form, function and therapeutic considerations for the epithelial barrier.

Current opinion in gastroenterology·2026
Same journal

Dietary protein as a regulator of colitis and colorectal cancer.

Current opinion in gastroenterology·2026
See all related articles

Related Experiment Video

Updated: Jul 15, 2025

Ileectomy-induced Bile Overaccumulation in Mouse Intestine
06:55

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

9.5K

Small intestinal bacterial overgrowth: current update.

Hammad Zafar1, Brenda Jimenez, Alison Schneider

  • 1Department of Gastroenterology, Hepatology and Nutrition, Cleveland Clinic Florida, Weston, Florida, USA.

Current Opinion in Gastroenterology
|September 26, 2023
PubMed
Summary
This summary is machine-generated.

This review covers small intestinal bacterial overgrowth (SIBO), detailing its causes, symptoms, and diagnostic methods. Emerging non-antibiotic treatments show promise for managing this condition.

More Related Videos

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
08:33

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

13.0K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.9K

Related Experiment Videos

Last Updated: Jul 15, 2025

Ileectomy-induced Bile Overaccumulation in Mouse Intestine
06:55

Ileectomy-induced Bile Overaccumulation in Mouse Intestine

Published on: August 21, 2017

9.5K
Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
08:33

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

13.0K
Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model
05:41

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

2.9K

Area of Science:

  • Gastroenterology
  • Microbiology

Background:

  • Small intestinal bacterial overgrowth (SIBO) is characterized by excess bacteria in the small intestine, leading to diverse gastrointestinal symptoms like bloating, diarrhea, and malabsorption.
  • Traditionally diagnosed via jejunal aspirate, SIBO presents with symptoms including bloating, abdominal distension, diarrhea, nutrient deficiencies, and weight loss.

Approach:

  • This review synthesizes current knowledge on SIBO, covering its etiology, risk factors, clinical presentation, and diagnostic strategies.
  • Discusses advancements in diagnostic tools such as breath, capsule, and urine-based testing, enhancing diagnostic accuracy.
  • Explores therapeutic options, including traditional antibiotic treatments and novel non-antibiotic approaches like probiotics, dietary changes, and prokinetic agents.

Key Points:

  • Recent diagnostic advancements, including breath, capsule, and urine tests, have improved the detection of SIBO.
  • Non-antibiotic treatment strategies are emerging as effective alternatives or adjuncts to traditional therapies.
  • SIBO diagnosis relies on identifying bacterial overgrowth or altered composition in the small intestine, impacting nutrient absorption and causing GI distress.

Conclusions:

  • Updated diagnostic methods offer improved yield and accessibility for SIBO detection.
  • Non-antibiotic therapies present a promising frontier in SIBO management, potentially reducing reliance on antibiotics.
  • Comprehensive management of SIBO involves accurate diagnosis and tailored therapeutic strategies, including novel approaches.