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Related Concept Videos

Analgesia and Pain Management01:25

Analgesia and Pain Management

649
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
649
Peripheral Artery Disease V: Postoperative Nursing Management01:23

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During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
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Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

326
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
326

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Related Experiment Video

Updated: Jul 15, 2025

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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PROSPECT methodology for developing procedure-specific pain management recommendations: an update.

G P Joshi1, E Albrecht2, M Van de Velde3

  • 1Department of Anaesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Anaesthesia
|September 26, 2023
PubMed
Summary
This summary is machine-generated.

The PROSPECT group updated its methodology for creating evidence-based procedure-specific pain management recommendations. Revisions enhance rigor and transparency by refining inclusion criteria and adopting new quality assessment tools.

Keywords:
analgesiaevidence-based medicinemethodologypostoperative painrecommendations

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Area of Science:

  • Pain Management
  • Evidence-Based Medicine
  • Clinical Practice Guidelines

Background:

  • The Procedure-Specific Postoperative Pain Management (PROSPECT) working group provides evidence-based recommendations.
  • Existing PROSPECT methodology has limitations and areas for improvement.
  • New factors have been identified to enhance the methodology.

Purpose of the Study:

  • To present updated PROSPECT methodology for developing procedure-specific pain management recommendations.
  • To detail methodological revisions for improved rigor and transparency.
  • To outline future PROSPECT working group procedures.

Main Methods:

  • Implementing prospective registration of randomized clinical trials.
  • Excluding specific placebo-controlled studies (paracetamol, NSAIDs, COX-2 inhibitors, opioids) and drug-class comparisons.
  • Utilizing the Cochrane Collaboration risk of bias tool for quality assessment.
  • Employing a modified Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach for evidence and recommendations.

Main Results:

  • The updated methodology incorporates prospective trial registration.
  • Specific study designs and drug comparisons will be excluded from future reviews.
  • Enhanced tools for assessing evidence quality and recommendation strength will be used.

Conclusions:

  • The revised PROSPECT methodology increases rigor and transparency in developing pain management guidelines.
  • Updated procedures ensure a more robust and reliable evidence-based approach.
  • These changes will lead to improved procedure-specific pain management recommendations.