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Updated: Jul 15, 2025
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
Published on: May 27, 2022
Blood-Based Biomarkers for Neuroprognostication in Acute Brain Injury
Andrew M Nguyen1, Vishal Saini1, H E Hinson2
1Neurosciences Critical Care Program, Department of Neurology, Oregon Health & Science University, Portland, Oregon.
Abstract:
Acute brain injury causes loss of functionality in patients that often is devastating. Predicting the degree of functional loss and overall prognosis requires a multifaceted approach to help patients, and more so their families, make important decisions regarding plans and goals of care. A variety of blood-based markers have been studied as one aspect of this determination. In this review, we discuss CNS-derived and systemic markers that have been studied for neuroprognostication purposes. We discuss the foundation of each protein, the conditions in which it has been studied, and how the literature has used these markers for interpretation. We also discuss challenges to using each marker in each section as well.
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