Related Experiment Video

Updated: Jul 15, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
12:13

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

6.9K

Epithelial specific splicing regulator proteins as emerging oncogenes in aggressive prostate cancer

Rahul Advani1, Sara Luzzi1, Emma Scott1

  • 1Newcastle University Biosciences Institute (NUBI) and Newcastle University Cancer Centre, Newcastle University, Newcastle Upon Tyne, NE1 3BZ, United Kingdom.

Oncogene
|September 26, 2023
PubMed

Insights

Aggressively proliferating prostate tumors show increased expression of epithelial splicing regulators ESRP1 and ESRP2. These regulators may serve as lineage survival oncogenes, offering potential therapeutic targets for prostate cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • Prostate cancer progression is influenced by oncogenes, tumor suppressors, and steroid hormones.
  • Identifying aggressive prostate tumors remains a significant clinical challenge.
  • Aberrant splicing plays a crucial role in cancer development and progression.

Purpose of the Study:

  • To investigate the role of splicing regulators ESRP1 and ESRP2 in prostate cancer.
  • To evaluate ESRP1 and ESRP2 as potential biomarkers for aggressive prostate tumors.
  • To explore ESRP1/2 as therapeutic targets for prostate cancer treatment.

Main Methods:

  • Analysis of ESRP1 and ESRP2 expression in prostate primary tumors.
  • Correlation of ESRP1/2 expression with tumor proliferation and aggressiveness.
  • In silico analysis to identify ESRP1/2-regulated gene targets.

Main Results:

  • Elevated expression of ESRP1 and ESRP2 identifies aggressively proliferating prostate primary tumors.
  • ESRP1 and ESRP2 function as master regulators of epithelial splicing patterns.
  • ESRP1/2 expression is associated with more aggressive disease progression in prostate cancer.

Conclusions:

  • ESRP1 and ESRP2 are identified as lineage survival oncogenes in prostate cancer.
  • Targeting ESRP1/2 activity or their splice isoforms may offer novel therapeutic strategies.
  • Caution is needed to avoid promoting metastasis through targeting ESRP1/2 due to potential mesenchymal splicing shifts.

More Related Videos

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition11:48

Detection of Alternative Splicing During Epithelial-Mesenchymal Transition

Published on: October 9, 2014

13.0K
Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells10:06

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

9.0K

Related Concept Videos

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
56.5K
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
21.2K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
What is Gene Expression?01:36

What is Gene Expression?

A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
8.6K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a...
6.3K