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Updated: Jul 22, 2026
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Summary
Thyroid cancer patients exhibit distinct digital-palmar dermatoglyphics, including lower total ridge counts and altered pattern formations. These dermatoglyphic variations may serve as potential, though not conclusive, indicators.
Area of Science:
- Genetics
- Dermatology
- Oncology
Background:
- Dermatoglyphics, the study of skin patterns, offers insights into developmental variations.
- Thyroid cancer is a significant health concern with diverse etiological factors.
- Investigating potential correlations between dermatoglyphic patterns and thyroid cancer could reveal novel diagnostic or prognostic markers.
Purpose of the Study:
- To investigate qualitative and quantitative differences in digito-palmar dermatoglyphics between individuals with thyroid cancer and a healthy control group.
- To explore potential associations between dermatoglyphic variations, clinicopathological features, and ABO blood groups in thyroid cancer patients.
Main Methods:
- Qualitative and quantitative analysis of digito-palmar dermatoglyphics in 93 thyroid cancer patients and 200 healthy controls.
- Comparison of total digital ridge count (TDRC), ridge count between a-d triradii, and pattern analysis (e.g., A line transversality/obliquity, interdigital patterns, sulcus transversus).
- Exploration of correlations with thyroid cancer subtypes and ABO blood groups.
Main Results:
- Thyroid cancer subjects showed a significantly lower TDRC and reduced ridge count between a-d triradii compared to controls.
- The A line exhibited increased transversality in male cancer patients and obliquity in female cancer patients.
- Increased interdigital patterns and a higher incidence of sulcus transversus were observed in the thyroid cancer group.
- Some qualitative and quantitative dermatoglyphic variations were noted in relation to specific histopathological forms and ABO blood groups, but lacked statistical conclusiveness.
Conclusions:
- Significant differences in digito-palmar dermatoglyphics exist between thyroid cancer patients and healthy individuals.
- Specific dermatoglyphic features, such as reduced TDRC and altered pattern formations, are associated with thyroid cancer.
- While preliminary associations with histopathology and blood groups were observed, further research is needed to establish conclusive links.
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