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Related Concept Videos

Cerebrospinal Fluid01:21

Cerebrospinal Fluid

Cerebrospinal fluid (CSF) is a colorless liquid that flows around the brain and the spinal cord, playing a vital role in the protection, support, and overall function of the central nervous system (CNS). CSF production, circulation, and absorption are tightly regulated processes essential for the brain and spinal cord to function properly.
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.

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Liquid biopsy: creating opportunities in brain space.

Rakesh Trivedi1, Krishna P Bhat2,3,4

  • 1Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. rtrivedi1@mdanderson.org.

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Liquid biopsy offers a minimally invasive way to detect and track brain tumors like glioblastoma using biomarkers in blood and cerebrospinal fluid (CSF). This approach aids in real-time analysis of tumor changes, overcoming limitations of traditional tissue biopsies.

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Area of Science:

  • Oncology
  • Biomarker Discovery
  • Neuroscience

Background:

  • Tissue biopsy poses challenges for brain tumors (e.g., glioblastoma) due to limited accessibility and risks.
  • Liquid biopsy provides a non-invasive alternative for collecting tumor-derived analytes from biofluids.
  • Blood and cerebrospinal fluid (CSF) are key biofluids for detecting circulating tumor biomarkers.

Purpose of the Study:

  • To review liquid biopsy biomarkers for brain tumors.
  • To discuss applications, challenges, and advances in liquid biopsy for neuro-oncology.
  • To provide an overview of ongoing clinical trials in this field.

Main Methods:

  • Literature review of studies on liquid biopsy in brain tumor patients.
  • Analysis of circulating cellular and acellular analytes in biofluids.
  • Examination of genetic, epigenetic, transcriptomic, proteomic, and metabolomic alterations.

Main Results:

  • Liquid biopsy enables repetitive, minimally invasive collection of diverse tumor biomarkers.
  • Analyte detection facilitates real-time monitoring of molecular changes in brain tumors.
  • Significant progress has been made in identifying and utilizing liquid biopsy biomarkers.

Conclusions:

  • Liquid biopsy is a promising tool for diagnosing and monitoring brain tumors, especially glioblastoma.
  • It overcomes limitations of tissue biopsy, offering real-time molecular insights.
  • Continued technological advancements and clinical trials are crucial for its widespread adoption.