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Platelet glutathione peroxidase activity is impaired in patients with coronary heart disease

G Guidi, R Schiavon, I Sheiban

    Scandinavian Journal of Clinical and Laboratory Investigation
    |October 1, 1986
    PubMed

    Insights

    Platelet glutathione peroxidase (GSH-Px) activity is lower in patients with coronary artery stenosis, correlating with increased oxidative stress markers. This suggests reduced GSH-Px may be a risk factor for coronary artery disease.

    Area of Science:

    • Biochemistry
    • Cardiovascular Medicine
    • Nutritional Science

    Background:

    • Platelets play a crucial role in hemostasis and thrombosis.
    • Oxidative stress is implicated in the pathogenesis of cardiovascular diseases.
    • Glutathione peroxidase (GSH-Px) is a key antioxidant enzyme.

    Purpose of the Study:

    • To investigate platelet glutathione peroxidase (GSH-Px) activity in patients with coronary artery stenosis.
    • To assess the relationship between GSH-Px activity and markers of oxidative stress in these patients.
    • To explore the potential role of GSH-Px deficiency as a risk factor for coronary artery disease.

    Main Methods:

    • Assessed platelet GSH-Px activity in 25 healthy individuals and 25 patients with coronary artery stenosis.
    • Measured malondialdehyde (MDA) production in platelets stimulated with sodium arachidonate.
    • Compared GSH-Px activity and MDA production between the two groups.

    Main Results:

    • Significantly reduced mean platelet GSH-Px activity was observed in patients with coronary artery stenosis compared to healthy individuals.
    • Significantly increased mean platelet MDA production was found in the patient group.
    • The findings suggest a link between impaired antioxidant defense and coronary artery disease.

    Conclusions:

    • Reduced platelet GSH-Px activity may be associated with increased oxidative stress (MDA production) in coronary artery disease.
    • Nutritional factors, such as selenium intake, might influence GSH-Px activity.
    • Low GSH-Px activity could represent a potential risk factor for the development of coronary artery disease.

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