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VIP and prolactin release in response to meals
Scandinavian Journal of Gastroenterology
|October 1, 1986
Summary
Vasoactive intestinal polypeptide (VIP) levels increase after high-fat meals, independent of body mass. Prolactin (PRL) levels remain unchanged, suggesting VIP release is triggered by duodenal fat content.
Area of Science:
- Gastroenterology
- Endocrinology
- Human Physiology
Background:
- Vasoactive intestinal polypeptide (VIP) and prolactin (PRL) are hormones with potential roles in digestive processes.
- Understanding hormonal responses to different macronutrient loads is crucial for comprehending digestion regulation.
Purpose of the Study:
- To investigate the distinct roles of VIP and PRL in digestion.
- To examine how plasma levels of VIP and PRL respond to high-carbohydrate versus high-fat-protein meals in premenopausal women.
Main Methods:
- Plasma VIP and PRL concentrations were measured in healthy, non-obese, and obese premenopausal women.
- Participants consumed isocaloric breakfasts with either high carbohydrate or high fat-protein content.
- Hormonal levels were analyzed post-meal to assess dietary impact.
Main Results:
- A significant elevation in plasma VIP concentration was observed following the high fat-protein breakfast.
- This VIP increase was independent of the women's body mass index (BMI).
- Plasma PRL levels showed no significant alteration in response to either breakfast composition.
Conclusions:
- Meal-induced VIP release appears to be primarily stimulated by high fat content in the duodenum.
- This VIP release may subsequently influence bicarbonate secretion and cholecystokinin release.
- PRL does not seem to play a significant role in the immediate digestive hormonal response to these meals.