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Updated: Jul 15, 2025

Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
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Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection

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Investigation of microbial coinfection in 453 septic COVID-19 patients admitted to hospital; a retrospective study

Armin Khavandegar1, Zeinab Siami2,3, Sogand Goudarzi4

  • 1Sina Trauma & Surgery Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Future Science OA
|September 27, 2023
PubMed
Abstract

Insights

Microbial coinfections are common in septic COVID-19 patients in Iran. These coinfections, particularly bacterial ones, significantly increase the risk of death, intubation, and ICU admission, worsening patient outcomes.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • COVID-19 (Coronavirus Disease 2019) can lead to severe illness, often complicated by secondary infections.
  • Microbial coinfections in patients with COVID-19 can significantly alter disease progression and patient prognosis.

Purpose of the Study:

  • To evaluate the incidence and impact of microbial coinfections in a cohort of septic COVID-19 patients in Iran.
  • To identify common causative agents of coinfections and their association with clinical outcomes.

Main Methods:

  • A single-center, retrospective observational study was conducted on 453 patients with septic COVID-19.
  • Patients' medical records were reviewed to identify microbial coinfections from respiratory and blood cultures.

Main Results:

  • A significant proportion of patients (21.9% with respiratory, 4.2% with blood cultures) had positive microbial cultures.
  • Klebsiella species were the most frequent isolates in both respiratory and blood samples.
  • Positive respiratory microbial cultures were associated with increased odds of death, intubation, ICU admission, and poorer discharge status.

Conclusions:

  • Microbial coinfections, including bacterial and fungal, are independent contributors to adverse outcomes in septic COVID-19 patients.
  • Early identification and management of coinfections are crucial for improving survival and clinical outcomes in severe COVID-19 cases.
Keywords:
COVID-19SARS-CoV-2bacterial coinfectioncoinfectionunderlying disease

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