Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.0K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.0K
Bone Remodeling01:40

Bone Remodeling

38.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.4K
Bone Disorders01:29

Bone Disorders

3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
Renal Drug Excretion: Overview01:15

Renal Drug Excretion: Overview

178
As primary excretory organs, the kidneys maintain homeostasis by removing waste substances from the bloodstream. They comprise over a million units called nephrons, which serve as the kidney's functional units.
A nephron consists of two primary structures: the renal corpuscle and the renal tubule. The renal corpuscle contains the glomerulus, a network of capillaries where the first step of renal excretion, glomerular filtration, occurs. Blood pressure forces water, ions, and small molecules...
178
What is the Skeletal System?01:02

What is the Skeletal System?

52.9K
Overview
52.9K
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

20
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage kidney disease (ESKD). At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate...
20

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lysosome-derived methylated arginine is a signalling metabolite controlling the lipidome.

Nature cell biology·2026
Same author

Management of Osteoporosis and Low Bone Mass in Kidney Disease.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Sequential therapeutic approach for the management of osteoporosis in people with chronic kidney disease.

Nature reviews. Nephrology·2026
Same author

High Prevalence of Secondary Hyperparathyroidism Prior to Kidney Transplantation in Brazil: A Perfect Storm for Adverse Graft Outcomes.

Kidney360·2026
Same author

Time-Lapse HR-pQCT: an in Vivo Imaging-Based Assessment of Bone Remodeling Dynamics.

Current osteoporosis reports·2026
Same author

Estrogen protects female mice with chronic kidney disease from fibroblast growth factor 23-induced left ventricular hypertrophy.

Kidney international·2026
Same journal

Sex differences in renal acid-base regulation.

Current opinion in nephrology and hypertension·2026
Same journal

Primary prevention of chronic kidney disease in type 2 diabetes mellitus with sodium-glucose cotransporter 2 inhibitors.

Current opinion in nephrology and hypertension·2026
Same journal

Financial and policy challenges of delivering kidney replacement therapies in resource-limited settings.

Current opinion in nephrology and hypertension·2026
Same journal

The role of kir4.1/Kir5.1 in mediating the effect of angiotensin-II on Na-Cl-cotransporter.

Current opinion in nephrology and hypertension·2026
Same journal

Role of the calcium-sensing receptor in regulating calcium transport in the thick ascending limb.

Current opinion in nephrology and hypertension·2026
Same journal

Social determinants of chronic kidney disease: from association to clinical and population action.

Current opinion in nephrology and hypertension·2026
See all related articles

Related Experiment Video

Updated: Jul 15, 2025

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

13.5K

Renal osteodystrophy: something old, something new, something needed.

Valentin David1, Isidro B Salusky2, Hartmut Malluche3

  • 1Division of Nephrology and Hypertension, Department of Medicine, and Center for Translational Metabolism and Health, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Current Opinion in Nephrology and Hypertension
|September 27, 2023
PubMed
Summary
This summary is machine-generated.

Renal osteodystrophy (ROD) is a bone disorder in chronic kidney disease (CKD) patients. A new biorepository offers integrated data to advance ROD research and develop better treatments.

More Related Videos

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

367
Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

24.2K

Related Experiment Videos

Last Updated: Jul 15, 2025

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts
07:13

Application of Retinoic Acid to Obtain Osteocytes Cultures from Primary Mouse Osteoblasts

Published on: May 13, 2014

13.5K
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
04:23

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy

Published on: February 21, 2025

367
Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

24.2K

Area of Science:

  • Bone Metabolism Research
  • Chronic Kidney Disease (CKD) Pathophysiology
  • Skeletal Health in CKD

Background:

  • Renal osteodystrophy (ROD) is a prevalent complication in chronic kidney disease (CKD) patients.
  • ROD leads to significant morbidity, including fractures, bone loss, and increased mortality.
  • Current treatments for ROD are insufficient, highlighting the need for improved understanding and therapies.

Conclusions:

  • An open-access NIH-funded resource sharing bone-tissue information from ROD patients is critical.
  • This resource will accelerate the discovery of new insights into ROD pathogenesis and pathophysiology.
  • Facilitating hypothesis-driven research will inform the development of disease-modifying and prevention strategies for ROD.