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Related Experiment Video

Updated: Jul 15, 2025

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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Gut microbiota and acne: A Mendelian randomization study.

Qiurui Cao1, Jinyan Guo1, Shuangqing Chang1

  • 1Department of Anorectal Surgery, Jiangmen Wuyi Hospital of Traditional Chinese Medicine, Jiangmen, China.

Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [And] International Society for Digital Imaging of Skin (ISDIS) [And] International Society for Skin Imaging (ISSI)
|September 27, 2023
PubMed
Summary

This study used Mendelian randomization to investigate the causal link between gut bacteria and acne. Certain gut bacteria like Bacteroides may worsen acne, while others like Ruminococcus may improve it.

Keywords:
GWASMendelian randomizationacnecausal effectgut microbiota

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Area of Science:

  • Microbiome research
  • Genetics
  • Dermatology

Background:

  • Observational studies suggest a link between gut microbiota composition and acne development.
  • Causal inference is needed to confirm the relationship between gut bacteria and acne.

Purpose of the Study:

  • To investigate the causal relationship between gut microbiota and acne using Mendelian randomization.
  • To identify specific gut bacteria that may influence acne onset.

Main Methods:

  • Utilized summary statistics from the MiBioGen and FinnGen consortiums.
  • Employed Mendelian randomization with methods like IVW, MR Egger, weighted median, and weighted mode.
  • Conducted analyses for heterogeneity, horizontal pleiotropy, and performed leave-one-out analysis.

Main Results:

  • Bacteroides and Allisonella were associated with an increased risk of acne (OR > 1).
  • Ruminococcus torques group showed a protective effect against acne (OR < 1).
  • Candidatus soleaferrea, Eubacterium coprostanoligenes group, Fusicatenibacter, and Lactobacillus exhibited suggestive protective associations with acne (OR < 1).

Conclusions:

  • The study provides evidence for a causal effect of gut microbiota on acne development.
  • Specific gut bacterial taxa may play a role in the pathogenesis or prevention of acne.