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Related Experiment Videos

Distant heart procurement for transplantation.

D C Watson, B A Reitz, W A Baumgartner

    Surgery
    |July 1, 1979
    PubMed
    Summary
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    Utilizing donor hearts from distant hospitals for cardiac transplantation yielded comparable outcomes to using local donor hearts. This practice expands the donor pool for heart transplant recipients without compromising results.

    Area of Science:

    • Cardiology
    • Transplantation Medicine
    • Surgical Outcomes

    Background:

    • Cardiac transplantation is a life-saving procedure for end-stage heart failure.
    • Donor heart availability is a significant limiting factor in expanding heart transplantation.
    • Procurement of donor hearts from distant locations may increase the donor pool but raises concerns about ischemia time and outcomes.

    Purpose of the Study:

    • To compare the outcomes of cardiac transplantation using donor hearts procured from distant hospitals versus local hospitals.
    • To evaluate the impact of increased ischemia time associated with distant heart procurement on patient survival and graft function.

    Main Methods:

    • Retrospective analysis of 39 cardiac transplants performed between January 1977 and September 1978.

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  • Comparison of recipient and donor characteristics, focusing on ischemia time (local vs. distant procurement).
  • Assessment of key outcomes including immediate myocardial function, need for inotropic support, 90-day mortality, serum enzyme levels, rejection, infection, and histological findings.

    • Main Results:

    • Donor hearts from distant hospitals had significantly longer mean ischemia times (154 minutes) compared to local hearts (52 minutes).
    • Overall mortality rates were similar between the distant (32%) and local (40%) heart groups.
    • No significant differences were observed in immediate myocardial function, postoperative support, early/late mortality, enzyme levels, rejection, or infection rates.

    Conclusions:

    • Cardiac transplantation using donor hearts from distant hospitals yields results comparable to those using locally procured hearts.
    • Distant heart procurement effectively expands the donor pool for potential cardiac recipients.
    • Increased ischemia time in distant procurements did not adversely affect short-term or long-term transplant outcomes in this cohort.