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Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
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Polyurethane Degradable Hydrogels Based on Cyclodextrin-Oligocaprolactone Derivatives.

Alexandra-Diana Diaconu1, Corina-Lenuta Logigan2, Catalina Anisoara Peptu2

  • 1"Petru Poni" Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda 41A, 700487 Iasi, Romania.

Gels (Basel, Switzerland)
|September 27, 2023
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Summary
This summary is machine-generated.

New degradable hydrogels made from cyclodextrin and polyethylene glycol show tunable properties and drug delivery potential. These advanced polymer networks offer promising applications in various fields.

Keywords:
crosslinkingcyclodextrindegradabledynamic rheologyhydrogelisophorone diisocyanatelevofloxacinoligocaprolactonepolyethylene glycol

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomedical Engineering

Background:

  • Polymer networks are crucial for drug delivery and tissue engineering.
  • Cyclodextrin and polyethylene glycol (PEG) offer unique properties like hydrophilicity and host-guest complexation.
  • Developing degradable polymer networks with controlled properties is an ongoing challenge.

Purpose of the Study:

  • To synthesize and characterize novel, hydrolytically degradable polymer networks.
  • To investigate the influence of cyclodextrin content on network properties and drug loading/release.
  • To evaluate the potential of these hydrogels for drug delivery applications.

Main Methods:

  • Polyaddition crosslinking of cyclodextrin and PEG using isophorone diisocyanate.
  • Custom modification of cyclodextrin with oligocaprolactone for degradability.
  • Characterization using Scanning Electron Microscopy (SEM), Differential Thermogravimetric Analysis (DTG), and Fourier-Transform Infrared Spectroscopy (FTIR).
  • Dynamic rheology, thermal water swelling, and hydrolytic degradation studies.
  • Drug loading and release studies using levofloxacin as a model drug.

Main Results:

  • Successful synthesis of crosslinked polymer networks with confirmed morphology and structure.
  • Demonstrated tunable hydrophilic character and encapsulation capacity.
  • Hydrolytic degradability was achieved through oligocaprolactone modification.
  • Dynamic rheology and swelling studies revealed network connectivity and the impact of cyclodextrin concentration.
  • Levofloxacin release studies indicated potential for controlled drug delivery.

Conclusions:

  • The developed cyclodextrin-PEG based hydrogels are hydrolytically degradable and possess tunable properties.
  • The amount of cyclodextrin significantly influences the network's connectivity, swelling, and degradation behavior.
  • These materials show promise for drug encapsulation and controlled release applications.