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Biocompatible Anisole-Nonlinear PEG Core-Shell Nanogels for High Loading Capacity, Excellent Stability, and

Jing Shen1,2, Jiangtao Zhang1, Weitai Wu3

  • 1Department of Chemistry of The College of Staten Island and PhD Program in Chemistry of Graduate Center, The City University of New York, 2800 Victory Boulevard, Staten Island, NY 10314, USA.

Gels (Basel, Switzerland)
|September 27, 2023
PubMed
Summary

Researchers developed biocompatible poly(vinyl anisole)@nonlinear poly(ethylene glycol) (PVAS@PEG) nanogels to improve curcumin delivery. These nanogels enhance curcumin

Keywords:
anisolebiocompatiblecore–shell nanogelscurcumin stabilitydrug deliveryhigh loading capacitynonlinear PEGthermo-responsive

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Curcumin exhibits therapeutic potential for diabetes and cancers but suffers from poor bioavailability due to low water solubility and rapid degradation.
  • Effective delivery systems are crucial to overcome curcumin's limitations and harness its medicinal properties.

Purpose of the Study:

  • To engineer biocompatible poly(vinyl anisole)@nonlinear poly(ethylene glycol) (PVAS@PEG) core-shell nanogels for enhanced curcumin delivery.
  • To investigate the effect of PEG shell thickness on nanogel properties and curcumin release kinetics.

Main Methods:

  • Synthesis of PVAS@PEG core-shell nanogels with varying PEG shell thicknesses.
  • Characterization of nanogel morphology, size, and curcumin loading capacity.
  • Evaluation of curcumin stability, in vitro release profile, cellular uptake, and cytotoxicity.

Main Results:

  • Monodispersed spherical PVAS@PEG nanogels with controllable size and shell thickness were successfully prepared.
  • Optimized nanogels achieved a high curcumin loading capacity of 38.0 wt%, stabilized curcumin degradation, and demonstrated thermo-responsive release.
  • Nanogels exhibited effective cellular uptake and negligible cytotoxicity in B16F10 and HL-7702 cells.

Conclusions:

  • PVAS@PEG core-shell nanogels represent a promising platform for improving curcumin's bioavailability and therapeutic efficacy.
  • The tunable nature of these nanogels allows for controlled drug loading and release, offering potential for efficient drug delivery applications.