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Updated: Jul 15, 2025

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
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Beyond Participation: Evaluating the Role of Patients in Designing Oncology Clinical Trials

Eliya Farah1, Matthew Kenney1, Anris Kica1

  • 1Life-Saving Therapies Network, 173 Heath Street, Ottawa, ON K1H 8L6, Canada.

Current Oncology (Toronto, Ont.)
|September 27, 2023
PubMed

Insights

Active patient engagement in oncology clinical trial design improves outcomes and patient experiences. Prioritizing patient values is crucial for future cancer research, moving beyond simple participation.

Area of Science:

  • Oncology
  • Clinical Trials
  • Patient Engagement

Background:

  • Historically, oncology clinical trials relied on experts, with limited patient input in design.
  • Patient participation was key, but their active role in decision-making was restricted.

Purpose of the Study:

  • To review the literature on active patient engagement in oncology clinical trial design.
  • To assess the influence of patient involvement on clinical trial outcomes.

Main Methods:

  • Systematic literature search conducted in MEDLINE (Ovid) and EMBASE.
  • Included studies focused on patient engagement in cancer clinical research design.

Main Results:

  • Seven studies met eligibility criteria, highlighting benefits of active patient involvement.
  • Benefits included enhanced recruitment strategies and more patient-centered outcomes.
  • Patient involvement led to tangible developments (e.g., resources) and indirect impacts (e.g., adherence).

Conclusions:

  • Future oncology trials must prioritize patient values and perspectives.
  • Regulatory bodies should encourage patient centricity through guidelines.
  • Patient involvement in research should expand beyond participation to active design contributions.
Keywords:
design oncology clinical trialevidence-based patient engagementoncology clinical trialpatient centricity

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