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Diffuse Large B-Cell Lymphoma of the Frontal Sinus: A Case Report
Anastasia Urbanelli1, Francesca Testi1, Giuseppe Riva1
1Division of Otorhinolaryngology, Department of Surgical Sciences, University of Turin, Via Genova 3, 10126 Turin, Italy.
Hematology Reports
|September 27, 2023
Summary
Diffuse large B-cell lymphoma (DLBCL) is a rare but aggressive cancer affecting the frontal sinus. Early diagnosis is challenging due to its similarity to other nasal conditions, often delaying critical treatment.
Area of Science:
- Oncology
- Hematology
- Otorhinolaryngology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is the most common Non-Hodgkin Lymphoma (NHL).
- Primary sinonasal NHL is exceptionally rare, presenting diagnostic and therapeutic hurdles.
- DLBCL can affect virtually any organ, including rare presentations in the sinonasal tract.
Observation:
- A 49-year-old woman presented with diplopia and right superior eyelid swelling.
- Clinical, radiological, and histological findings confirmed DLBCL of the right frontal sinus.
- The tumor invaded subcutaneous soft tissues and the intracranial frontal region.
Findings:
- The patient received multiple chemotherapy regimens (MATRIX, R-DA-EPOCH) and CAR-T therapy.
- Despite aggressive treatment, the patient's condition was refractory.
- The patient died 11 months post-diagnosis.
Implications:
- DLBCL of the frontal sinus poses significant diagnostic challenges, often mimicking other sinonasal pathologies.
- Delayed diagnosis in sinonasal DLBCL can impede timely and effective treatment initiation.
- This case highlights the critical need for heightened awareness and diagnostic vigilance for rare sinonasal malignancies.
