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Polyacrylate-Cholesterol Amphiphilic Derivative: Formulation Development and Scale-up for Health Care Applications.

Marco Viola1, Claudia Migliorini1, Fabio Ziarelli2

  • 1Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Rome, Italy.

Journal of Functional Biomaterials
|September 27, 2023
PubMed
Summary
This summary is machine-generated.

A novel polymer, PAAbCH, acts as a versatile excipient for pharmaceutical and cosmetic products. It enhances solubility, viscosity, and emulsification, with successful pre-industrial scale-up demonstrated.

Keywords:
amphiphiliccholesterolemulsifierpolyacrylatesolid-state NMRtopical formulations

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Pharmaceutical Sciences

Background:

  • Novel amphiphilic polyacrylate grafted with cholesterol moieties (PAAbCH) was previously synthesized.
  • Characterization and application studies are essential for novel excipient development.

Purpose of the Study:

  • To deeply characterize PAAbCH.
  • To investigate its potential in pharmaceutical and cosmetic formulations.
  • To assess its scalability for pre-industrial applications.

Main Methods:

  • Solid-state Nuclear Magnetic Resonance (NMR) analysis for polymer structure confirmation.
  • Formulation of water-based products including oil/water emulsions and medicated films.
  • Development of polyelectrolyte hydrogel complexes with chitosan at macro- and nano-scales.

Main Results:

  • PAAbCH structure was confirmed by solid-state NMR.
  • Stable oil/water emulsions with various lipids were successfully prepared.
  • Hydrophilic medicated films with prolonged diclofenac release were developed.
  • PAAbCH formed macro- and nano-scale hydrogel complexes with chitosan.

Conclusions:

  • PAAbCH demonstrates significant potential as an innovative pharmaceutical and cosmetic excipient.
  • Its functions include solubility enhancement, viscosity modification, and emulsification.
  • The polymer exhibits a facile scale-up transfer process for pre-industrial applications.