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BoDV-1 Infection in Children and Adolescents: A Systematic Review and Meta-Analysis

Matteo Riccò1, Ilaria Zanella2, Elia Satta2

  • 1Occupational Health and Safety Service on the Workplace/Servizio di Prevenzione e Sicurezza Ambienti di Lavoro (SPSAL), Department of Public Health, AUSL-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.

Pediatric Reports
|September 27, 2023
PubMed

Insights

Borna disease virus 1 (BoDV-1) circulates in children and adolescents, with a 6.09% seroprevalence for antibodies. This suggests potential unknown transmission routes in younger populations.

Area of Science:

  • Virology
  • Epidemiology
  • Pediatrics

Background:

  • Borna disease virus 1 (BoDV-1) causes severe meningo-myeloencephalitis in humans.
  • The epidemiology of BoDV-1, particularly in pediatric populations, requires further clarification.

Purpose of the Study:

  • To systematically review and summarize the seroprevalence of BoDV-1 in children and adolescents (<18 years old).
  • To assess the circulation of BoDV-1 within this demographic group.

Main Methods:

  • Systematic literature search across PubMed, EMBASE, and MedRxiv databases.
  • Inclusion of studies reporting BoDV-1 antigen and antibody seroprevalence rates in subjects under 18.
  • Pooled analysis of data from six identified studies involving 2692 subjects.

Main Results:

  • A pooled seroprevalence of 6.09% (95% CI 2.14–16.17) for BoDV-1 antibodies was calculated.
  • A pooled seroprevalence of 0.76% (95% CI 0.26–2.19) for BoDV-1 antigens was determined.
  • Significant heterogeneity was observed in the prevalence estimates.

Conclusions:

  • Seroprevalence data indicate substantial circulation of BoDV-1 among children and adolescents.
  • Limited exposure opportunities suggest potential involvement of unknown vectors in BoDV-1 transmission to younger individuals.

Keywords:
BoDV-1BornavirusELISAmeningo-myeloencephalitisseroprevalence

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