Related Experiment Video

Updated: Jul 15, 2025

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

1.6K

How gallic acid regulates molecular signaling: role in cancer drug resistance

Samira Hassani1, Fahimeh Ghanbari2, Marzieh Lotfi3,4

  • 1Department of Plant and Animal Biology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.

Medical Oncology (Northwood, London, England)
|September 27, 2023
PubMed

Insights

Gallic acid (GA), a plant-derived phenolic compound, shows significant antitumor properties against chemotherapy-resistant cancers. It effectively combats multidrug resistance (MDR) and prevents cancer progression, invasion, and metastasis.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Cancer is a complex and heterogeneous disease often developing drug resistance, necessitating novel therapeutic agents.
  • Phenolic compounds, like Gallic acid (GA), are explored for their anticancer potential due to their ability to target diverse molecular pathways.
  • Multidrug resistance (MDR) remains a significant challenge in cancer treatment, leading to therapeutic failure and recurrence.

Purpose of the Study:

  • To review the therapeutic potential of Gallic acid (GA) as an anticancer agent.
  • To explore the antitumor properties of GA across various cancer types.
  • To discuss the role of GA in overcoming multidrug resistance (MDR) and its targeted delivery using nanocarriers.

Main Methods:

  • Literature review of studies investigating Gallic acid (GA) and its effects on cancer.
  • Analysis of molecular mechanisms targeted by GA in cancer cells.
  • Examination of research on GA's efficacy in preclinical and clinical cancer models.
  • Review of nanocarrier-based delivery systems for GA.

Main Results:

  • Gallic acid (GA) exhibits significant antitumor properties, inhibiting cancer progression, cell invasion, and metastasis.
  • GA demonstrates efficacy as a complementary agent to conventional chemotherapy, particularly in overcoming multidrug resistance (MDR).
  • Targeted delivery of GA using nanocarriers enhances its therapeutic potential and bioavailability.

Conclusions:

  • Gallic acid (GA) represents a promising natural compound for cancer therapy, especially for drug-resistant malignancies.
  • GA's multifaceted mechanisms of action and compatibility with nanodelivery systems warrant further clinical investigation.
  • GA holds potential as a valuable agent in combating cancer and overcoming therapeutic resistance.
Keywords:
CancerDrug resistanceGallic acidMolecular pathway

More Related Videos

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down08:59

Looking for Driver Pathways of Acquired Resistance to Targeted Therapy: Drug Resistant Subclone Generation and Sensitivity Restoring by Gene Knock-down

Published on: December 11, 2017

7.2K
Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.7K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.5K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K