Effects of Air Pollution Exposure during Preconception and Pregnancy on Gestational Diabetes Mellitus

This study aimed to investigate the association between air pollution and gestational diabetes mellitus (GDM) in small- and medium-sized cities, identify sensitive periods and major pollutants, and explore the effects of air pollution on different populations. A total of 9820 women who delivered in Handan Maternal and Child Health Hospital in the Hebei Province from February 2018 to July 2020 were included in the study. Logistic regression and principal component logistic regression models were used to assess the effects of air pollution exposure during preconception and pregnancy on GDM risk and the differences in the effects across populations. The results suggested that each 20 μg/m³ increase in PM_2.5 and PM₁₀ exposure during preconception and pregnancy significantly increased the risk of GDM, and a 10 μg/m³ increase in NO₂ exposure during pregnancy was also associated with the risk of GDM. In a subgroup analysis, pregnant women aged 30-35 years, nulliparous women, and those with less than a bachelor's education were the most sensitive groups. This study provides evidence for an association between air pollution and the prevalence of GDM, with PM_2.5, PM₁₀, and NO₂ as risk factors for GDM.