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Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review.
Harrison J Hansford1,2, Aidan G Cashin1,2, Matthew D Jones1,2
1School of Health Sciences, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.
Reporting of observational studies emulating target trials is inconsistent. A new guideline may improve clarity and quality of these important medical and policy studies.
Area of Science:
- Health research methodology
- Epidemiology
- Clinical trial design
Background:
- Observational studies emulating target trials are increasingly used for medical and policy decisions.
- Clear reporting is crucial for quality appraisal, evidence synthesis, and policy translation.
- The reporting quality of these specific study designs is not well understood.
Conclusions:
- Reporting of how target trials were emulated in observational studies is inconsistent.
- A dedicated reporting guideline for target trial emulation studies could enhance the quality and transparency of these studies.
- Improved reporting is needed to support reliable evidence for medical and policy decision-making.
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