Toward Personalized Medicine Approaches for Parkinson Disease Using Digital Technologies

Area of Science:

• Neurodegenerative Disorders
• Personalized Medicine
• P4 Medicine

Background:

• Parkinson disease (PD) affects over 10 million globally, causing significant motor and cognitive impairment with a substantial economic burden.
• Diverse patient phenotypes exhibit varied symptoms, medication responses, and disease progression, complicating treatment strategies.
• The long prodromal period of PD offers a window for early, personalized interventions.

Purpose of the Study:

• To explore personalized approaches to symptom management and disease control in Parkinson disease.
• To highlight opportunities for applying P4 medicine principles (predict, prevent, personalize, participate) to PD.
• To introduce the concept of composite orthogonal patient monitoring for tailored interventions.

Main Methods:

• Review of current understanding of PD heterogeneity and therapeutic challenges.
• Conceptual framework for integrating emerging diagnostic and monitoring strategies.
• Leveraging observational patient cohorts for refining intervention approaches.

Main Results:

• Identified opportunities for personalized interventions based on distinct patient phenotypes.
• Proposed P4 medicine as a framework for tailoring diagnostic and monitoring strategies.
• Emphasized the potential of composite orthogonal patient monitoring for individualized care.

Conclusions:

• Personalized P4 medicine approaches, including composite orthogonal monitoring, hold promise for optimizing Parkinson disease management.
• Tailored interventions can potentially delay disease onset and progression, influenced by factors like oxidative stress.
• These strategies may also inform therapeutic development for related neurodegenerative diseases like Alzheimer and Huntington disease.