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PROSPECTIVE SINGLE CENTER ANALYSIS OF OUTCOME STEM CELLS TRANSPLANTS IN PATIENTS WITH CEREBRAL PALSY

Nasser Ghaly Yousif1, Maitham G Yousif2, Ahmed Abd Ulhadi Mohsen3

  • 1DEPARTMENT OF MEDICINE, MEDICAL COLLEGE, AL MUTHANNA UNIVERSITY, SAMAWAH, IRAQ.

Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego
|September 27, 2023
PubMed

Insights

Autologous bone marrow-derived mononuclear stem cell transplantation shows significant improvements in gross motor function and other neurological symptoms in children with cerebral palsy, with no major adverse effects observed.

Area of Science:

  • Regenerative Medicine
  • Pediatric Neurology
  • Stem Cell Therapy

Background:

  • Cerebral palsy (CP) is a group of disorders affecting movement and posture, posing significant challenges for affected children.
  • Current treatments for CP offer symptomatic relief but do not address the underlying neurological damage.
  • Novel therapeutic strategies, including stem cell transplantation, are being explored to improve outcomes for children with CP.

Purpose of the Study:

  • To evaluate the efficacy and safety of intrathecal autologous bone marrow-derived mononuclear stem cell transplantation in children diagnosed with cerebral palsy.
  • To assess the impact of this therapy on gross motor function and other neurological symptoms.

Main Methods:

  • Thirty-five children with cerebral palsy (Gross Motor Function Classification System levels I-V, aged 8 months to 8 years) received intrathecal transplantation of autologous bone marrow mononuclear cells (BMMNCs).
  • BMMNCs were isolated using density gradient centrifugation, with cell viability confirmed to be approximately 98%.
  • Patients received granulocyte-colony stimulating factor (G-CSF) and BMMNCs were administered intrathecally in the L4-L5 region.

Main Results:

  • Following a 3-month follow-up, 80% of patients demonstrated improvement.
  • Significant improvements were noted in gross motor function (p=0.01), speech (p=0.04), neck holding (p=0.0003), sitting balance (p=0.04), and postural tone (p=0.0003).
  • A reduction in seizure frequency (p=0.04) and enhancement in cognition (p=0.01) were also observed.

Conclusions:

  • Intrathecal transplantation of autologous bone marrow-derived mononuclear stem cells is a safe and effective therapy for children with cerebral palsy.
  • This stem cell therapy demonstrates a significant positive effect on gross motor function and other neurological aspects of cerebral palsy.
  • The procedure showed minimal adverse effects, suggesting its potential as a viable treatment option.
Abstract

Keywords:
stem cells transplantsGMFCbone marrow aspirationcerebral palsy

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