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Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

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Published on: November 14, 2017

Very Early-Life Risk Factors for Developing Dementia: Evidence From Full Population Registers.

Martin Fischer^1,2, Martin Lövdén³, Therese Nilsson^4,5

¹Department of Clinical Sciences/Faculty of Medicine, Lund University, Malmö, Skåne County, Sweden.

The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences

|September 27, 2023

Summary

Early life conditions like advanced maternal age, close sibling spacing, and twin births are linked to increased dementia risk. Addressing these early-life factors may help reduce future dementia cases.

Keywords:

Birth characteristics Dementia risk Demographic risk factors Early life

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Area of Science:

Neuroscience
Public Health
Epidemiology

Background:

Early-life conditions significantly impact brain development.
Identifying early-life risk factors for dementia is crucial for prevention strategies.
Administrative data can serve as a proxy for historical birth complication records.

Purpose of the Study:

To assess the association between early-life risk factors and dementia risk.
To investigate the impact of demographic birth characteristics on long-term dementia risk.
To derive proxy indicators for birth complications from administrative data.

Main Methods:

Utilized Swedish administrative data for cohorts born 1932-1950 with multigenerational linkages.
Derived three birth risk factors: advanced maternal age, narrow sibling spacing, and twin births.
Applied survival analysis and controlled for socio-economic status and sibling design.

Main Results:

At least one birth risk factor was associated with increased dementia risk (HR=1.059).
Twin births showed a particularly heightened dementia risk (HR=1.166).
Demographic birth characteristics demonstrated relevant effect sizes compared to low education.

Conclusions:

Improving the early-life environment can potentially mitigate dementia risk.
Demographic birth characteristics are significant risk factors for dementia.
Support for births with complications may reduce future dementia cases.