Related Experiment Video
Updated: Jun 9, 2026

11:05
Investigation of Genetic Dependencies Using CRISPR-Cas9-based Competition Assays
Published on: January 7, 2019
9.5K
A human genome editing-based MLL::AF4 ALL model recapitulates key cellular and molecular leukemogenic features
Clara Bueno1,2,3, Raul Torres-Ruiz1,4,5,6,7, Talia Velasco-Hernandez1,2
1Stem Cell Biology, Immunotherapy and Developmental Leukemia Laboratory. Josep Carreras Leukemia Research Institute, Barcelona, Spain.
Blood
|September 27, 2023
Abstract:
Cellular ontogeny and MLL breakpoint site influence the capacity of MLL-edited CD34+ hematopoietic cells to initiate and recapitulate infant patients' features in pro-B-cell acute lymphoblastic leukemia (B-ALL). We provide key insights into the leukemogenic determinants of MLL-AF4+ infant B-ALL.

