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Updated: Jul 15, 2025
Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Gram-negative bacteria of critical priority in ICU patients from a tertiary care hospital]
Andrés Humberto Uc-Cachón1, Gloria María Molina-Salinas1, Angel de Jesús Dzul-Beh1
1Instituto Mexicano del Seguro Social, Hospital de Especialidades No. 1 "Lic. Ignacio García Téllez", Unidad de Investigación Médica Yucatán. Mérida, Yucatán, México.
Background:
Intensive care units (ICU) are the epicenter of antimicrobial resistance (AMR), and patients' infections are mainly caused by Gram-negative bacteria (GNB).
Objective:
To describe the frequency and trends in AMR of GNB deriving from the clinical samples of ICU patients at a tertiary care hospital in Mérida, Yucatán.
Material And Methods:
Study which included the review of laboratory reports of all bacteriological samples collected from patients admitted to neonatal, pediatric and adult ICU from January 1 2019 to December 31 2021.
Results:
433 GNB isolates were recovered, with Klebsiella pneumoniae being the most predominant isolate (n = 117; 27.02%). The majority of GNB were recovered from bronchial secretions (n = 163). Overall, GNB showed high resistance rates to ampicillin (89.48%), ampicillin/sulbactam (66.85%), cephalosporins (58.52-93.81%), tobramycin (58.06%), and tetracycline (61.73%). Among GNB, 73.90% and 68.53% exhibited multidrug-resistant, and highly resistant microorganisms' profiles, respectively, and 47.54% of Acinetobacter baumannii exhibited an extensively drug-resistant profile. A total of 80.33% of A. baumannii was carbapenem-resistant, and 83.76% of K. pneumoniae strains were ESBL-producing.
Conclusion:
Our data could be helpful to improve the empirical therapy and the infection-control program.
Insights
Antimicrobial resistance (AMR) in intensive care units (ICUs) is a major concern. Gram-negative bacteria (GNB) in ICUs show high resistance rates, with Klebsiella pneumoniae and Acinetobacter baumannii being predominant.
Area of Science:
- Infectious Diseases
- Microbiology
- Critical Care Medicine
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