Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

811
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
811
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A new recombinant avian metapneumovirus vaccine candidate provides complete protection against the novel variant infectious bursal disease virus in chickens.

Veterinary research·2026
Same author

Interface engineering of ultrathin nickel metallene on titanium dioxide nanosheets for efficient photocatalytic hydrogen evolution.

Journal of colloid and interface science·2026
Same author

Boundary echo control of S0-mode lamb waves using gradient phononic crystals.

Ultrasonics·2026
Same author

A Machine Learning Framework Integrating DeepLabCut and SimBA for Quantifying Aggressive Behavior in Swimming Crab <i>Portunus trituberculatus</i>.

Animals : an open access journal from MDPI·2026
Same author

Hydrogenation of CO<sub>2</sub> to Methanol Catalyzed by In<sub>2</sub>O<sub>3</sub>: Oxygen Vacancies, Surface Hydroxyl Groups, and Temperature Dependence for Reactivity Revealed by <sup>17</sup>O NMR.

Angewandte Chemie (International ed. in English)·2026
Same author

Preparation of a Novel Fe/Ca Modified Chlorella Biochar for Phosphorus Removal from Mariculture Tail Water by Response Surface Methodology.

Materials (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jul 15, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

10.5K

Enterococcus faecium C171: Modulating the Immune Response to Acute Lethal Viral Challenge.

Jielan Mi1, Tana He1, Xinyun Hu1

  • 1State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.

International Journal of Antimicrobial Agents
|September 27, 2023
PubMed
Summary

Enterococcus faecium C171 shows strong anti-inflammatory and anti-infective effects, reducing mortality in chickens by 75%. Its extracellular vesicles also mediate immune activation, suggesting potential for treating inflammatory diseases and viral infections.

Keywords:
Acute inflammationAnti-infectiveAnti-inflammatoryBacterial extracellular vesiclesEnterococcus faeciumIBDVImmunomodulatoryInfectious bursal disease virusProbiotics

More Related Videos

Author Spotlight: Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis
06:57

Author Spotlight: Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis

Published on: May 12, 2023

2.3K
Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-&#947; Responses
10:10

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

13.7K

Related Experiment Videos

Last Updated: Jul 15, 2025

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
08:32

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production

Published on: March 2, 2014

10.5K
Author Spotlight: Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis
06:57

Author Spotlight: Adjuvant Activity of Mycobacterium paratuberculosis in Enhancing the Immunogenicity of Autoantigens During Experimental Autoimmune Encephalomyelitis

Published on: May 12, 2023

2.3K
Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-&#947; Responses
10:10

Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

Published on: November 16, 2016

13.7K

Area of Science:

  • Microbiology
  • Immunology
  • Gastroenterology

Background:

  • Commensal bacteria play a crucial role in modulating host immune responses to infections.
  • Enterococcus faecium C171, a newly isolated strain, exhibits characteristics similar to known probiotics, including significant anti-inflammatory and anti-infective properties.

Purpose of the Study:

  • To investigate the immunomodulatory and anti-infective effects of Enterococcus faecium C171 and its extracellular vesicles.
  • To evaluate the therapeutic potential of E. faecium C171 in a chicken model of acute infectious disease.

Main Methods:

  • In vitro assays to assess the inhibition of pro-inflammatory mediators like pro-Caspase-1 and interleukin-1β (IL-1β).
  • Transwell system experiments to confirm inflammatory inhibition.
  • Oral administration of E. faecium C171 in specific pathogen-free (SPF) chickens challenged with a virulent infectious disease.
  • Analysis of gut microbiota composition, immune cell populations (CD3+, CD4+, CD8+), T cell proliferation, and interferon-γ secretion.

Main Results:

  • E. faecium C171 inhibited pro-Caspase-1 and IL-1β production in vitro.
  • Bacterial extracellular vesicles (Efm-C171-BEVs) were identified as key mediators of anti-infective and immune-activating effects.
  • Oral administration of E. faecium C171 increased beneficial gut bacteria (Enterococcus, Lactobacillus) in SPF chickens.
  • E. faecium C171 significantly reduced mortality by 75% in chickens challenged with infectious disease.
  • Treatment boosted immunoregulatory and killer T cells, enhanced T cell proliferation, and increased interferon-γ secretion.

Conclusions:

  • Enterococcus faecium C171 demonstrates potent anti-inflammatory and anti-infective capabilities, partly mediated by its extracellular vesicles.
  • E. faecium C171 effectively modulates the gut microbiota and enhances cellular and humoral immunity in a host model.
  • Both E. faecium C171 and its extracellular vesicles (Efm-C171-BEVs) show promise as adjuvant therapies for acute inflammatory conditions and viral infections.