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Relationship between injectate volume and disposition in erector spinae plane block: a cadaveric study
Jeffrey Gadsden1, Jeffrey Gonzales2, An Chen3
1Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina, USA jeff.gadsden@duke.edu.
Regional Anesthesia and Pain Medicine
|September 27, 2023
Summary
Increasing injectate volume in erector spinae plane (ESP) blocks enhances anesthetic spread. Optimal injection volumes of 30 mL may provide analgesia across 4-7 levels without affecting anterior structures.
Area of Science:
- Anesthesiology
- Anatomy
- Pain Management
Background:
- Erector spinae plane (ESP) blocks are utilized for analgesia after thoracoabdominal and lumbar spine surgeries.
- The impact of injectate volume and location on anesthetic spread in ESP blocks requires further clarification.
Purpose of the Study:
- To investigate the relationship between injectate volume and the cephalocaudal spread of anesthetics in ESP blocks.
- To determine the optimal injectate volume for effective analgesia.
Main Methods:
- Ultrasound-guided ESP injections were performed on cadavers using contrast dye and saline.
- Real-time fluoroscopy assessed cephalocaudal spread after incremental injections.
- Cadaveric dissection documented dye distribution within anatomical structures.
Main Results:
- Larger injection volumes correlated with more extensive cephalocaudal spread.
- Dissection revealed staining ventral to the erector spinae muscle spanning 4-7 levels with 30-40 mL injections, and 12-13 levels with 60-80 mL injections.
- No spread to the lamina, transverse processes, paravertebral space, epidural space, or pleura was observed.
Conclusions:
- Increased injectate volume in ESP blocks leads to greater cephalocaudal spread.
- Anesthetic spread reached the dorsal rami and ventral erector spinae muscle.
- 30 mL injections may be optimal for achieving 4-7 level analgesia.

