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Published on: November 27, 2019
Clinical Aspects and Etiologic Investigation of Pediatric Patients With Acute Liver Failure
Michele Luglio1, Tatiana de Carvalho Silva Marques2, Maria Fernanda Badue Pereira3
1Instituto da Criança e do Adolescente do Hospital das Clínicas da FMUSP, São Paulo, Brazil; Pediatric Intensive Care Center, Instituto da Criança e do Adolescente da Faculdade de Medicina da Universidade de São Paulo.
Abstract:
A new outbreak of hepatitis of unknown origin raised awareness in the international community. A few reports have attempted to associate new cases with adenovirus infection and the immunologic effects of previous SARS-CoV-2 infections through a superantigen mechanism. Moreover, according to a case series, viral isolates were identified in 7 of 10 cases of pediatric patients with hepatitis of unknown origin and acute liver failure. Adenovirus was detected by respiratory secretion polymerase chain reaction in 2 patients, with neither presenting with SARS-CoV-2 acute infection. Clinical and laboratory descriptions and cross-referencing epidemiologic and pathophysiological data can help identify possible disease etiologies.
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