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Assessment of lung hyperinflation in occupational chronic obstructive pulmonary disease: a multicentric
Virginie de Broucker1,2, Pascal Andujar3,4, Pierre-Marie Wardyn5,6
1ULR 4483 - IMPECS - IMPact de l'Environnement Chimique sur la Santé humaine, University of Lille, Lille, France virginie.debroucker@chru-lille.fr.
Abstract:
Occupational exposure is associated with elevated morbidity and lower quality of life in patients with chronic obstructive pulmonary disease (COPD). Static hyperinflation is an independent risk factor for all-cause mortality in COPD and for COPD exacerbation. In a multicentre, cross-sectional study (BPROFETIO), we sought to analyse the relationship between static hyperinflation and occupational exposure in patients with COPD with or without occupational exposure.
Material And Methods:
An overall 'whole working life' cumulative exposure index was calculated for occupational patients with COPD. Spirometry indices and lung volumes were measured according to the 2005 American Thoracic Society/European Respiratory Society guidelines.
Results:
After adjustment for age, sex, height, body mass index, smoking and coexposure, the analysis for each occupational hazard showed a higher risk for hyperinflation and FEV1 decline or progression of COPD or GOLD stage for patients with COPD exposed to non-metallic inorganic dusts.
Conclusion:
Occupational exposures should be more investigated in clinical practice and studies as they contribute to the COPD heterogeneity and are associated for some with the development of a static hyperinflation; a condition that is known to have a negative impact on quality of life and survival.
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