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Updated: Jul 15, 2025

Analysis of Translation in the Developing Mouse Brain using Polysome Profiling
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Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex

Iva Salamon1,2, Yongkyu Park1, Terezija Miškić3

  • 1Department of Neuroscience and Cell Biology, Rutgers University, Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.

Nature Communications
|September 27, 2023
PubMed
Summary

This study reveals that the RNA binding protein CELF4 regulates synaptic development in the prenatal human brain. Its disruption impacts synapse balance, potentially explaining sex differences in neurodevelopmental disorders.

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