Pre- and post-treatment evaluation of routine blood analysis in patients with attention deficit hyperactivity
Erdoğan Öz1, Mehmet Emin Parlak2, Yaşar Kapıcı3
1Adıyaman Provincial Health Directorate, Adiyaman, Turkey.
Insights
Children with attention deficit hyperactivity disorder (ADHD) show increased inflammation markers compared to healthy peers. Atomoxetine treatment partially improved these inflammation indicators in ADHD patients.
Area of Science:
- Pediatric Hematology
- Neuroinflammation Research
- Child Psychiatry
Background:
- Attention Deficit Hyperactivity Disorder (ADHD) is a common neurodevelopmental disorder.
- Emerging evidence suggests a potential link between ADHD and inflammatory processes.
- Hematologic parameters may serve as objective indicators of inflammation in ADHD.
Purpose of the Study:
- To investigate differences in hematologic inflammation markers between children with ADHD and healthy controls.
- To assess the impact of atomoxetine treatment on these inflammation markers in children with ADHD.
Main Methods:
- A case-control study involving 43 children (22 with ADHD, 21 healthy), aged 6-13 years.
- Comprehensive blood tests including complete blood count, albumin, CRP, and other biochemical markers were performed.
- ADHD patients received atomoxetine treatment, with follow-up blood tests after one month.
Main Results:
- Children with ADHD exhibited significantly higher neutrophil, platelet, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and pan-immune-inflammation value (PIV).
- Lymphocyte counts were significantly lower in the ADHD group compared to controls.
- Atomoxetine treatment led to a significant increase in lymphocyte and albumin levels in ADHD patients.
Conclusions:
- The study indicates elevated inflammation in drug-naive ADHD patients.
- Atomoxetine treatment demonstrated a partial amelioration of these inflammatory markers.
- Further research with larger cohorts and longer follow-up periods is warranted to fully understand the long-term effects of treatment on inflammation in ADHD.
Abstract:
This study aimed to examine potential disparities in hematologic inflammation parameters between children diagnosed with attention deficit hyperactivity disorder (ADHD) and their healthy counterparts and to determine whether atomoxetine treatment induced any alterations in inflammation indicators. This case-control study involved 43 children aged 6-13 years, 22 diagnosed with ADHD for the first time, and 21 healthy children. In all children, complete blood count and albumin, C-reactive protein (CRP), thyroid stimulating hormone (TSH), free thyroxine (free T4), folate, vitamin B12, aspartate aminotransferase (AST), alanine transaminase (ALT), creatinine and urea values were performed. Children with ADHD were started on atomoxetine treatment, and one month later, the blood test was repeated for those who commenced treatment. Neutrophil (p = 0.005), platelet (PLT) (p = 0.002), neutrophil/lymphocyte ratio (NLR) (p = 0.001), platelet/lymphocyte ratio (PLR) (p < 0.001), systemic immune /inflammation index (SII) (p < 0.001) and pan-immune-inflammation value (PIV) (p = 0.025) parameters were found to be significantly higher than the control group, while the lymphocyte value (p = 0.001) was found to be significantly lower. In those in the ADHD group, lymphocyte (p = 0.041) and albumin (p = 0.027) values increased significantly after treatment. The results of this study show the increase in inflammation in drug-naive ADHD patients and the partial improvement after treatment. However, there is a need to evaluate inflammation in larger samples after longer-term treatments and follow-ups.
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