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Hypersensitive C-reactive protein as a potential indicator for predicting left ventricular hypertrophy in elderly
Wei Song1,2, Chunsheng Zhang1, Jiamei Tang3
1Department of Cardiology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Insights
Elevated hypersensitive C-reactive protein (hs-CRP) levels are linked to left ventricular hypertrophy (LVH) in elderly hypertensive patients. hs-CRP ≥ 1.25 mg/L is an independent predictor of LVH, showing good diagnostic value.
Area of Science:
- Cardiology
- Geriatrics
- Biomarkers
Background:
- Hypertension is prevalent in elderly populations.
- Left ventricular hypertrophy (LVH) is a common complication of hypertension.
- Investigating novel biomarkers for LVH is crucial for early detection and management.
Purpose of the Study:
- To examine the association between hypersensitive C-reactive protein (hs-CRP) and LVH in elderly hypertensive individuals.
- To determine if hs-CRP can serve as a predictor for LVH in this demographic.
Main Methods:
- A cross-sectional study included 365 elderly hypertensive patients (≥65 years).
- Participants were categorized into LVH (n=134) and non-LVH (n=231) groups based on echocardiography.
- Spearman correlation, univariate, and multivariate analyses were used to assess the relationship between hs-CRP and LVH.
Main Results:
- The incidence of LVH was 36.7% in the study population.
- hs-CRP levels were significantly higher in the LVH group compared to the non-LVH group (P=0.002).
- hs-CRP showed a positive correlation with LVMI, IVST, and LVPWT (all P<0.001).
- hs-CRP ≥ 1.25 mg/L demonstrated a sensitivity of 57.5% and specificity of 78.4% for LVH diagnosis (AUC=0.710).
- hs-CRP ≥ 1.25 mg/L was an independent risk factor for LVH (adjusted OR=3.964, P<0.001).
Conclusions:
- A significant association exists between hs-CRP levels and LVH in elderly hypertensive patients.
- hs-CRP ≥ 1.25 mg/L is a potential independent predictor of LVH.
- hs-CRP exhibits good diagnostic efficacy for identifying LVH in this population.
Background:
The aim of this study was to investigate the relationship between Hypersensitive C-reactive protein (hs-CRP) and left ventricular hypertrophy (LVH) in elderly community-dwelling patients with hypertension.
Methods:
A cross-sectional study was conducted, involving the recruitment of 365 elderly hypertensive residents ≥ 65 years of age from five communities. The participants were divided into two groups: an LVH group (n = 134) and a non-LVH group (n = 231), based on the left ventricular mass index (LVMI) determined by echocardiography. Spearman correlation analysis was used to assess the relationship between hs-CRP and LVH. Univariate and Multivariate analysis was performed to detect variables associated with LVH. The diagnostic value of hs-CRP for LVH was expressed as the area under the receiver operating characteristic (ROC) curve.
Results:
The incidence of LVH in elderly hypertension patients in the community was 36.7%. The hs-CRP levels were significantly higher in subjects with LVH compared to those without LVH (1.9 [0.8, 2.9] vs. 0.7 [0.4, 1.4], P = 0.002). Spearman correlation analysis demonstrated a positive correlation between hs-CRP and LVMI (r = 0.246, P < 0.001), as well as with IVST (r = 0.225, P < 0.001) and LVPWT (r = 0.172, P = 0.001). Among elderly hypertensive residents in the community, the cut-off value of hs-CRP for diagnosing LVH was 1.25 mg/L (sensitivity: 57.5%; specificity: 78.4%), and the area under the ROC curve for hs-CRP to predict LVH was 0.710 (95%CI: 0.654-0.766; P < 0.001). In the final model, hs-CRP ≥ 1.25 mg/L (OR = 3.569; 95%CI, 2.153-5.916; P<0.001) emerged as an independent risk factor for LVH. This association remained significant even after adjusting for various confounding factors (adjusted OR = 3.964; 95%CI, 2.323-6.765; P < 0.001).
Conclusions:
This community-based cohort of elderly hypertensive individuals demonstrates a strong association between hs-CRP levels and the presence of LVH. The hs-CRP ≥ 1.25 mg/L may serve as an independent predictor for LVH in hypertensive subjects and exhibit good diagnostic efficacy for LVH.
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