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Developmental Exposure to Kynurenine Affects Zebrafish and Rat Behavior
Marta Marszalek-Grabska1, Kinga Gawel1, Nataliia Kosheva1
1Department of Experimental and Clinical Pharmacology, Medical University, Jaczewskiego 8b, 20-090 Lublin, Poland.
Cells
|September 28, 2023
Summary
Kynurenine (KYN) supplementation during early development impacts offspring behavior. Zebrafish larvae exposed to KYN showed altered behavior, suggesting KYN
Area of Science:
- Developmental Biology
- Neuroscience
- Metabolomics
Background:
- Proper nutrition is vital for fetal development.
- Kynurenine (KYN) is a key metabolite influencing neurodevelopment.
- Early embryonic effects of KYN remain unstudied.
Purpose of the Study:
- To investigate KYN's impact on early embryonic development.
- To assess KYN's effect on zebrafish larval behavior.
- To determine KYN's influence on rat offspring neurobehavior.
Main Methods:
- Incubation of zebrafish embryos/larvae with KYN at different stages.
- Administration of KYN to pregnant rats during early gestation (ED 1-7).
- Behavioral analysis of 5-day-old zebrafish and adult rat offspring.
Main Results:
- KYN incubation altered zebrafish behavior, particularly from 1-72 hpf and 49-72 hpf.
- Early KYN administration in rats led to subtle neurobehavioral changes in offspring.
- The larval zebrafish model proved effective in demonstrating KYN's developmental effects.
Conclusions:
- KYN influences early embryonic and larval development, affecting behavior.
- Early KYN exposure can cause subtle neurobehavioral alterations in offspring.
- Zebrafish models offer a valuable tool for studying neurodevelopmental disorders and drug metabolism.
