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Therapeutic Oligonucleotides: An Outlook on Chemical Strategies to Improve Endosomal Trafficking

Priyanka Mangla1, Quentin Vicentini1,2, Annabelle Biscans1

  • 1Oligonucleotide Discovery, Discovery Sciences Research and Development, AstraZeneca, 431 38 Gothenburg, Sweden.

Cells
|September 28, 2023
PubMed

Keywords:
antisense oligonucleotides (ASOs)cleavable linkersendosomal escapeendosomolytic agentslinker chemistrynon-cleavable linkersoligonucleotide conjugatesoligonucleotide deliveryoligonucleotide therapeuticspH-sensitive linkerssiRNA

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