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Updated: Jul 15, 2025

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Spreading Senescent Cells' Burden and Emerging Therapeutic Targets for Frailty

Serena Marcozzi1,2, Giorgia Bigossi1, Maria Elisa Giuliani1

  • 1Advanced Technology Center for Aging Research and Geriatric Mouse Clinic, IRCCS INRCA, 60121 Ancona, Italy.

Cells
|September 28, 2023
PubMed

Insights

Cellular senescence, the accumulation of aging cells, contributes to frailty. Understanding how senescent cells spread, influenced by factors like the microbiome, can reveal new therapeutic targets for aging.

Area of Science:

  • Gerontology
  • Cellular Biology
  • Immunology

Background:

  • Cellular senescence is a key driver of aging and age-related diseases.
  • The accumulation of senescent cells contributes to tissue dysfunction and the aging phenotype.
  • Frailty is a complex geriatric syndrome associated with increased vulnerability and mortality.

Purpose of the Study:

  • To review the mechanisms of senescent cell spreading and its impact on frailty.
  • To explore the role of age-related factors, including microbiome and virome alterations, in senescent cell accumulation.
  • To discuss potential therapeutic strategies targeting cellular senescence for frailty.

Main Methods:

  • This is a perspective review, synthesizing existing literature.
  • Analysis of age-related biological factors influencing senescent cell burden.
  • Focus on musculoskeletal and cerebral functions in the context of frailty.

Main Results:

  • Senescent cell burden is implicated in the development and progression of frailty.
  • Alterations in the microbiome and virome contribute to the loss of control over senescent cell accumulation.
  • Musculoskeletal and cerebral functions are particularly affected by senescent cell accumulation.

Conclusions:

  • Understanding senescent cell spreading mechanisms is crucial for elucidating frailty.
  • Microbiome and virome alterations are significant contributors to senescent cell-related frailty.
  • Targeting cellular senescence offers promising therapeutic avenues for frailty interventions.
Keywords:
agingcellular senescencefrailtyimmunosenescencemicrobiomevirome

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