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Glucocorticoid Receptor Signaling in NSCLC: Mechanistic Aspects and Therapeutic Perspectives

Kostas A Papavassiliou1, Nektarios Anagnostopoulos1, Athanasios G Papavassiliou2

  • 1First Department of Respiratory Medicine, 'Sotiria' Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.

Biomolecules
|September 28, 2023
PubMed

Insights

Glucocorticoid receptor (GR) signaling influences non-small cell lung cancer (NSCLC) progression and treatment response. Targeting GR may offer new therapeutic strategies for NSCLC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Non-small cell lung cancer (NSCLC) treatment is evolving with new targeted therapies.
  • The glucocorticoid receptor (GR) is implicated in NSCLC tumorigenesis and progression.
  • Glucocorticoids may modulate the efficacy of current NSCLC treatments.

Purpose of the Study:

  • To review the role of GR signaling in NSCLC.
  • To explore GR as a prognostic and predictive biomarker in NSCLC.
  • To discuss the therapeutic potential of glucocorticoids in NSCLC management.

Main Methods:

  • Literature review of recent advances in NSCLC biology and GR signaling.
  • Analysis of studies on GR expression and its association with NSCLC patient survival.
  • Examination of the impact of glucocorticoids on standard NSCLC therapies.

Main Results:

  • GR signaling plays a significant role in NSCLC development and progression.
  • GR expression may correlate with NSCLC patient survival outcomes.
  • Glucocorticoids can influence the effectiveness of chemotherapy, immunotherapy, and targeted therapy in NSCLC.

Conclusions:

  • GR is a potential prognostic and predictive biomarker for NSCLC.
  • Glucocorticoids hold therapeutic promise for NSCLC, both as standalone agents and in combination therapies.
  • Further research into GR-targeted strategies could improve NSCLC clinical outcomes.
Keywords:
glucocorticoid receptorglucocorticoidsnon-small cell lung cancer

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