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Updated: Jul 15, 2025
Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
Published on: October 28, 2021
Advances of Osteosarcoma Models for Drug Discovery and Precision Medicine
Linyun Tan1,2, Yitian Wang1,2, Xin Hu1,2
1Department of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu 610064, China.
Abstract:
The management of osteosarcoma (OS) patients presents a significant clinical challenge. Despite progress in conventional and targeted therapies, the survival rate of OS patients remains limited largely due to therapy resistance and the high metastatic potential of the disease. OS models that accurately reflect the fundamental characteristics are vital to the innovation and validation of effective therapies. This review provides an insight into the advances and challenges in OS drug development, focusing on various preclinical models, including cell lines, 3D culture models, murine models, and canine models. The relevance, strengths, and limitations of each model in OS research are explored. In particular, we highlight a range of potential therapeutics identified through these models. These instances of successful drug development represent promising pathways for personalized OS treatment.
Insights
Developing effective osteosarcoma (OS) therapies is challenging due to drug resistance and metastasis. This review examines preclinical OS models to advance drug development and personalized treatment strategies.
Area of Science:
- Oncology
- Translational Medicine
- Drug Development
Background:
- Osteosarcoma (OS) management is a significant clinical challenge, with limited survival rates due to therapy resistance and high metastatic potential.
- Effective preclinical models are crucial for developing and validating novel OS therapies.
Purpose of the Study:
- To review advances and challenges in osteosarcoma drug development.
- To explore various preclinical models used in OS research.
- To highlight potential therapeutics identified through these models.
Main Methods:
- Review of existing literature on osteosarcoma preclinical models.
- Analysis of cell lines, 3D culture models, murine models, and canine models.
- Evaluation of the relevance, strengths, and limitations of each model.
Main Results:
- Various preclinical models offer unique insights into osteosarcoma biology and drug response.
- Cell lines, 3D cultures, and animal models (murine, canine) have distinct advantages and disadvantages.
- Several potential therapeutics have been identified and validated using these models.
Conclusions:
- Preclinical models are essential for advancing osteosarcoma drug discovery.
- Understanding the strengths and limitations of each model is key to successful translation.
- Identified therapeutics show promise for personalized osteosarcoma treatment strategies.
