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Updated: Jul 15, 2025

NMR-Based Activity Assays for Determining Compound Inhibition, IC50 Values, Artifactual Activity, and Whole-Cell Activity of Nucleoside Ribohydrolases
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Ribonucleoside Hydrolases-Structure, Functions, Physiological Role and Practical Uses

Leonid A Shaposhnikov1,2, Svyatoslav S Savin1,2, Vladimir I Tishkov1,2

  • 1Bach Institute of Biochemistry, Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, Moscow 119071, Russia.

Biomolecules
|September 28, 2023
PubMed
Summary

Ribonucleoside hydrolases break down ribonucleosides. Their exact function in most organisms is still unknown, but this review explores their diverse types, roles, and applications.

Keywords:
cancer drug designcatalysis mechanismcrystal structureenzyme kineticsnucleoside hydrolases

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