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Strongly Metal-Adhesive and Self-Healing Gelatin@Polydopamine-Based Hydrogels with Long-Term Antioxidant Activity
Jordana Hirtzel1,2, Guillaume Leks1,3, Julie Favre1
13Bio, Laboratoire de Conception et Application de Molécules Bioactives, UMR 7199, Faculté de Pharmacie, Université de Strasbourg, CNRS, 74 Route du Rhin, 67401 Illkirch Cedex, France.
Antioxidants (Basel, Switzerland)
|September 28, 2023
Summary
This study developed a strong, self-healing, and antioxidant polydopamine-gelatin hydrogel for biomedical uses. The bioinspired adhesive demonstrates enhanced adhesion and antioxidant properties, showing promise for wound healing applications.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Adhesive Technology
Background:
- Bioinspired adhesives are crucial for biomedical applications.
- Developing materials with self-healing and antioxidant properties is a key challenge.
Purpose of the Study:
- To create a polydopamine-gelatin (PDA-gelatin) hydrogel with adhesive, antioxidant, and self-healing properties.
- To evaluate the mechanical, adhesive, and antioxidant performance of the PDA-gelatin hydrogel.
Main Methods:
- Oxidation of dopamine (DA) to polydopamine (PDA) in a gelatin mixture using sodium periodate (NaIO4).
- Rheological analysis to determine stiffness and thermal resistance.
- Adhesion testing to measure tensile work per unit area (W) at varying peeling rates.
- DPPH scavenging assay to assess antioxidant activity and stability over time.
Main Results:
- The PDA-gelatin hydrogel exhibited kPa stiffness and thermal resistance above 50 °C.
- Self-healing properties were observed after heating at 55 °C.
- Strong, rate-dependent adhesion to steel was achieved, with W up to 100 ± 39 J/m², 2.5 times higher than gelatin alone.
- Significant antioxidant activity was maintained for over 17 days.
Conclusions:
- PDA-gelatin hydrogel is a promising candidate for biomedical adhesives.
- The material offers a combination of enhanced adhesion, self-healing, and antioxidant capabilities.
- Its properties are relevant for applications in wound healing and other biomedical fields.
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