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Updated: Jul 16, 2026
Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
High Tumoral STMN1 Expression Is Associated with Malignant Potential and Poor Prognosis in Patients with
Kenjiro Ogushi1, Takehiko Yokobori1,2, Sumihito Nobusawa3
1Department of General Surgical Science, Graduate School of Medicine, Gunma University, Maebashi 371-8511, Japan.
Background:
Stathmin 1 (STMN1), a marker for immature neurons and tumors, controls microtubule dynamics by destabilizing tubulin. It plays an essential role in cancer progression and indicates poor prognosis in several cancers. This potential protein has not been clarified in clinical patients with neuroblastoma. Therefore, this study aimed to assess the clinical significance and STMN1 function in neuroblastoma with and without MYCN amplification.
Methods:
Using immunohistochemical staining, STMN1 expression was examined in 81 neuroblastoma samples. Functional analysis revealed the association among STMN1 suppression, cellular viability, and endogenous or exogenous MYCN expression in neuroblastoma cell lines.
Result:
High levels of STMN1 expression were associated with malignant potential, proliferation potency, and poor prognosis in neuroblastoma. STMN1 expression was an independent prognostic factor in patients with neuroblastoma. Furthermore, STMN1 knockdown inhibited neuroblastoma cell growth regardless of endogenous and exogenous MYCN overexpression.
Conclusion:
Our data suggest that assessing STMN1 expression in neuroblastoma could be a powerful indicator of prognosis and that STMN1 might be a promising therapeutic candidate against refractory neuroblastoma with and without MYCN amplification.
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