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Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
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Angiogenesis in Lung Cancer: Understanding the Roles of Growth Factors

Tchawe Yvan Sinclair Ngaha1,2, Angelina V Zhilenkova1, Freddy Elad Essogmo1

  • 1Institute for Personalized Oncology, Center for Digital Biodesign and Personalized Healthcare, First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), 8-2 Trubetskaya str., Moscow 119991, Russia.

Cancers
|September 28, 2023
PubMed

Insights

Growth factors drive lung cancer angiogenesis, fueling tumor progression. Anti-angiogenic therapies targeting growth factors show promise but require careful patient monitoring due to toxicity risks.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Growth factors play a critical role in lung cancer angiogenesis.
  • Angiogenesis supports tumor growth, invasion, metastasis, and immune modulation.
  • This highlights the need for targeted anti-angiogenic therapies.

Purpose of the Study:

  • To review the role of growth factors in lung cancer angiogenesis.
  • To discuss anti-angiogenic compounds targeting growth factor pathways.
  • To evaluate the efficacy and toxicity of these therapies.

Main Methods:

  • Review of existing research on growth factors and lung cancer.
  • Analysis of anti-angiogenic strategies targeting EGF and VEGF pathways.
  • Evaluation of clinical trial data for monotherapy and combination treatments.

Main Results:

  • Growth factors significantly promote lung cancer progression via angiogenesis.
  • Targeting EGF and VEGF families shows encouraging therapeutic potential.
  • Anti-angiogenic therapies demonstrate efficacy but carry risks of toxicity.

Conclusions:

  • Anti-angiogenic therapies targeting growth factors are a promising strategy for lung cancer.
  • Personalized patient follow-up is crucial to manage potential toxicities.
  • Further research is needed to optimize treatment protocols and minimize adverse effects.
Keywords:
angiogenesisanti-angiogenic therapygrowth factorslung cancertumor microenvironment

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