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Updated: Jul 15, 2025
Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Retrospective Study on Staphylococcus aureus Resistance Profile and Antibiotic Use in a Pediatric Population
Danilo Buonsenso1,2, Martina Giaimo1, Davide Pata1
1Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy.
Insights
Pediatric Staphylococcus aureus infections show high resistance to common antibiotics like oxacillin and cephalosporins. However, glycopeptides remain effective, highlighting the need for antibiotic stewardship in children.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Clinical Pharmacy
Background:
- Antibiotic resistance is a growing global health concern.
- Limited data exists on antibiotic resistance patterns in pediatric Staphylococcus aureus infections.
- Understanding resistance profiles is crucial for effective pediatric treatment.
Purpose of the Study:
- To investigate the antibiotic resistance profile of Staphylococcus aureus in pediatric patients.
- To analyze the therapeutic management of Staphylococcus aureus infections in children.
- To identify risk factors associated with antibiotic resistance in this population.
Main Methods:
- Retrospective study analyzing clinical data of 1210 infants and children.
- Inclusion criteria: antibiogram-associated Staphylococcus aureus infection.
- Analysis of resistance patterns against various antibiotic classes.
Main Results:
- High resistance rates observed: 61.5% to oxacillin, 58.4% to cephalosporins, 41.6% to aminoglycosides, 38.3% to fluoroquinolones.
- No resistance detected to glycopeptides, a critical antibiotic for MRSA.
- Key risk factors for resistance include neonatal age (0-28 days), presence of devices, and comorbidities.
Conclusions:
- Staphylococcus aureus exhibits significant antibiotic resistance in pediatric populations.
- Glycopeptides remain a viable treatment option for MRSA infections in children.
- Adherence to antibiotic stewardship principles is essential to combat rising resistance.
Abstract:
The growing phenomenon of antibiotic resistance and the presence of limited data concerning the pediatric area prompted us to focus on Staphylococcus aureus infection in this study, its antibiotic resistance profile, and the therapeutic management of affected children. We conducted a retrospective study by collecting clinical data on infants and children with antibiogram-associated S. aureus infection. We enrolled 1210 patients with a mean age of 0.9 years. We analyzed the resistance patterns and found 61.5% resistance to oxacillin, 58.4% resistance to cephalosporins, 41.6% resistance to aminoglycosides, and 38.3% resistance to fluoroquinolones. Importantly, we found no resistance to glycopeptides, a key antibiotic for MRSA infections whose resistance is increasing worldwide. We also found that the main risk factors associated with antibiotic resistance are being aged between 0 and 28 days, the presence of devices, and comorbidities. Antibiotic resistance is a growing concern; knowing the resistance profiles makes it possible to better target the therapy; however, it is important to use antibiotics according to the principles of antibiotic stewardship to limit their spread.
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