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Is There a Relationship between Adverse Pregnancy Outcomes and Future Development of Atherosclerosis?

Anastasia V Poznyak1, Victoria A Khotina2, Elena B Zhigmitova2

  • 1Institute for Atherosclerosis Research, Osennyaya 4-1-207, 121609 Moscow, Russia.

Biomedicines
|September 28, 2023
PubMed

Insights

Adverse pregnancy outcomes like gestational diabetes and hypertensive disorders are linked to later cardiovascular disease. Understanding these connections can reveal crucial gender-specific risk factors for atherosclerosis.

Area of Science:

  • Reproductive endocrinology and cardiovascular medicine.

Background:

  • Cardiovascular disease (CVD) is a leading global cause of mortality.
  • Early identification of CVD risk factors is crucial for effective management and prevention of atherosclerosis.
  • Adverse pregnancy outcomes affect over 30% of women and are increasingly recognized as potential indicators of future cardiovascular risk.

Purpose of the Study:

  • To review the association between adverse pregnancy outcomes and the development of atherosclerotic cardiovascular disease.
  • To explore the underlying mechanisms linking conditions such as gestational diabetes, hypertensive disorders of pregnancy, miscarriages, and stillbirths to female cardiovascular health.
  • To identify potential gender-specific risk factors for cardiovascular disease originating from pregnancy complications.

Main Methods:

  • Systematic review of recent scientific literature.
  • Analysis of data from studies investigating the pathophysiological links between specific pregnancy disorders and cardiovascular system implications.
  • Focus on mechanisms underlying gestational diabetes, hypertensive disorders of pregnancy, miscarriages, and stillbirths.

Main Results:

  • Evidence suggests a significant correlation between adverse pregnancy outcomes and an increased risk of postpartum cardiovascular disease.
  • Specific pregnancy complications share underlying mechanisms that contribute to the development of atherosclerosis.
  • These conditions may serve as early indicators of cardiovascular risk in women.

Conclusions:

  • Adverse pregnancy outcomes represent a critical window for assessing long-term cardiovascular health in women.
  • Understanding the shared pathways between pregnancy complications and atherosclerosis can lead to improved cardiovascular risk stratification and targeted interventions.
  • Further research into gender-specific cardiovascular risk factors stemming from pregnancy is warranted.

Keywords:
atherosclerosiscardiovascular risk factorsgestationpregnancy

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