Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Receptors: Overview01:22

Opioid Receptors: Overview

984
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
984
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

188
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
188
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

501
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
501
Prosopagnosia01:24

Prosopagnosia

198
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
198
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

283
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
283
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

326
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
326

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reactive oxygen species alter dopaminergic and purinergic signaling and microglia physiology in the nucleus accumbens.

bioRxiv : the preprint server for biology·2026
Same author

Circadian misalignment and adolescent obesity risk behaviors: physical & sedentary activity, dietary intake, and food reward.

Sleep advances : a journal of the Sleep Research Society·2026
Same author

Shared mechanisms of dopamine and ATP transmission in the nucleus accumbens.

bioRxiv : the preprint server for biology·2026
Same author

Glucose dysregulation and glycemic phenotyping in chronic migraine.

Frontiers in neurology·2026
Same author

Sex-Specific Electrocortical Interactions in a Color Recognition Task in Men and Women with Opioid Use Disorder.

Biomedicines·2025
Same author

Multimodal assessment of circadian sleep health in predicting mental health outcomes in adolescents.

Frontiers in sleep·2025
Same journal

Precision Proteomic Profiling of Systemic Lupus Erythematosus-Correlating Disease Activity and Complement Levels with Clinical Phenotypes.

Biomedicines·2026
Same journal

The Role of Salivary Microbiota in Pancreatic Cancer: From Screening to Tumor Progression and Treatment Response.

Biomedicines·2026
Same journal

Diagnostic Utility of Surface Electromyography for Identifying Muscles Affected by Myofascial Trigger Points: A Scoping Review.

Biomedicines·2026
Same journal

Performance Assessment of a Locally Semi-Automated NGS-Based Workflow for Homologous Recombination Deficiency Testing in High-Grade Serous Ovarian Carcinoma.

Biomedicines·2026
Same journal

Coupling and Uncoupling Pleiotropy Between Hypertension and Type 2 Diabetes Contribute to Exploring Potential Heterogeneity in Cardiovascular Risk in East Asian Population.

Biomedicines·2026
Same journal

Maternal Response to Therapeutic Plasma Exchange in Early Gestation: A Case Series of Thrombotic Microangiopathies and Neurological Disorders.

Biomedicines·2026
See all related articles

Related Experiment Video

Updated: Jul 15, 2025

A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

7.5K

Gender-Specific Interactions in a Visual Object Recognition Task in Persons with Opioid Use Disorder.

JoAnn Petrie1, Logan R Kowallis1, Sarah Kamhout1

  • 1Department of Psychology, Brigham Young University, Provo, UT 84602, USA.

Biomedicines
|September 28, 2023
PubMed
Summary
This summary is machine-generated.

Opioid use disorder (OUD) affects cognitive processing differently in men and women. This study found gender-specific changes in brain activity (EEG) and reaction times related to OUD, impacting performance reflection.

Keywords:
alpha and beta brain oscillationselectroencephalogram (EEG)event-related potentials (ERP)gender-specific differencesopioid use disorder (OUD)substance use disorder (SUD)visual attentionvisual cognitive processingvisual evoked potential (VEP)

More Related Videos

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.7K
Profiling Maternal Behavior Responses During Whole-Brain Imaging
07:12

Profiling Maternal Behavior Responses During Whole-Brain Imaging

Published on: January 24, 2025

790

Related Experiment Videos

Last Updated: Jul 15, 2025

A Conflict Model of Reward-seeking Behavior in Male Rats
06:11

A Conflict Model of Reward-seeking Behavior in Male Rats

Published on: February 20, 2019

7.5K
Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.7K
Profiling Maternal Behavior Responses During Whole-Brain Imaging
07:12

Profiling Maternal Behavior Responses During Whole-Brain Imaging

Published on: January 24, 2025

790

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Addiction Research

Background:

  • Opioid use disorder (OUD) overdose deaths are a global epidemic, with men experiencing higher mortality rates.
  • Understanding the cognitive underpinnings of OUD is crucial for developing targeted interventions.
  • Previous research indicates potential gender differences in OUD, but cognitive neuroscience aspects require further exploration.

Purpose of the Study:

  • To investigate gender-specific electroencephalographic (EEG) differences in individuals with OUD compared to controls during a cognitive task.
  • To examine how OUD affects event-related potentials (ERPs) like N200 and P300 and neural oscillations.
  • To explore gender-by-OUD interactions in cognitive processing and performance feedback.

Main Methods:

  • Controlled, cross-sectional, age-matched study design comparing male and female participants with and without OUD.
  • Utilized electroencephalography (EEG) to record brain activity during a visual object recognition Go/No-Go task.
  • Analyzed event-related potentials (N200, P300) and neural oscillations (alpha, beta power) in response to task stimuli and feedback.

Main Results:

  • Women exhibited slower reaction times than men overall.
  • Non-OUD controls showed gender differences in N200/P300 amplitudes and latencies.
  • OUD participants displayed gender-specific alterations in N200/P300 latencies and reduced alpha/beta power during feedback processing.

Conclusions:

  • Opioid use disorder influences cognitive processing in a gender-dependent manner.
  • EEG measures reveal distinct patterns of neural activity in men and women with OUD.
  • Findings highlight the importance of considering gender in the neuroscientific study of OUD and its cognitive consequences.