Related Experiment Video

Updated: Jul 15, 2025

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
06:36

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis

Published on: August 21, 2020

12.3K

Cellular and Molecular Processes in Wound Healing

Montserrat Fernández-Guarino1, Maria Luisa Hernández-Bule2, Stefano Bacci3

  • 1Dermatology Service, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), 28034 Madrid, Spain.

Biomedicines
|September 28, 2023
PubMed

Insights

This review explores cellular and molecular mechanisms in wound healing and scar formation. Understanding these processes is crucial for developing effective therapies for pathological scarring like keloids.

Area of Science:

  • Wound healing research
  • Pathological scarring
  • Regenerative medicine

Background:

  • Wound healing involves complex cellular and molecular events.
  • Pathological conditions like keloids represent poorly understood alterations in scar formation.
  • Current knowledge of these biological mechanisms remains incomplete.

Purpose of the Study:

  • To summarize recent advancements in understanding wound healing.
  • To highlight the gaps in knowledge regarding scar pathology.
  • To review emerging therapeutic strategies for abnormal scarring.

Main Methods:

  • Literature review of cellular and molecular processes in wound healing.
  • Analysis of pathological scar formation, focusing on keloids.
  • Survey of novel therapeutic approaches for scar-related conditions.

Main Results:

  • Recent progress in defining cellular and molecular pathways of wound repair.
  • Identification of significant knowledge deficits in the pathophysiology of keloids.
  • Overview of promising new treatments for excessive scarring.

Conclusions:

  • Further research is needed to fully elucidate wound healing and scar formation mechanisms.
  • A deeper understanding is essential for addressing pathological scarring effectively.
  • New therapies offer potential for improved management of keloid scars.
Keywords:
acute woundscellular infiltratechronic woundskeloidsscars

More Related Videos

Protocol to Create Chronic Wounds in Diabetic Mice06:55

Protocol to Create Chronic Wounds in Diabetic Mice

Published on: September 25, 2019

20.4K
Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing08:34

Microscopy Based Methods for the Assessment of Epithelial Cell Migration During In Vitro Wound Healing

Published on: January 2, 2018

9.4K

Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
6.0K
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
4.0K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
5.0K
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
4.9K
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.3K
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.5K