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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Updated: Jul 15, 2025

Murine Excisional Wound Healing Model and Histological Morphometric Wound Analysis
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Cellular and Molecular Processes in Wound Healing.

Montserrat Fernández-Guarino1, Maria Luisa Hernández-Bule2, Stefano Bacci3

  • 1Dermatology Service, Hospital Ramón y Cajal, Instituto Ramón y Cajal de Investigación Sanitaria (Irycis), 28034 Madrid, Spain.

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|September 28, 2023
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Summary

This review explores cellular and molecular mechanisms in wound healing and scar formation. Understanding these processes is crucial for developing effective therapies for pathological scarring like keloids.

Keywords:
acute woundscellular infiltratechronic woundskeloidsscars

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Area of Science:

  • Wound healing research
  • Pathological scarring
  • Regenerative medicine

Background:

  • Wound healing involves complex cellular and molecular events.
  • Pathological conditions like keloids represent poorly understood alterations in scar formation.
  • Current knowledge of these biological mechanisms remains incomplete.

Purpose of the Study:

  • To summarize recent advancements in understanding wound healing.
  • To highlight the gaps in knowledge regarding scar pathology.
  • To review emerging therapeutic strategies for abnormal scarring.

Main Methods:

  • Literature review of cellular and molecular processes in wound healing.
  • Analysis of pathological scar formation, focusing on keloids.
  • Survey of novel therapeutic approaches for scar-related conditions.

Main Results:

  • Recent progress in defining cellular and molecular pathways of wound repair.
  • Identification of significant knowledge deficits in the pathophysiology of keloids.
  • Overview of promising new treatments for excessive scarring.

Conclusions:

  • Further research is needed to fully elucidate wound healing and scar formation mechanisms.
  • A deeper understanding is essential for addressing pathological scarring effectively.
  • New therapies offer potential for improved management of keloid scars.