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A Key Role of CD8+ T Cells in Controlling of Tuberculosis Infection
Igor Kudryavtsev1,2, Yulia Zinchenko3, Maria Serebriakova1
1Institution of Experimental Medicine, Department of Immunology, 197376 St-Petersburg, Russia.
Diagnostics (Basel, Switzerland)
|September 28, 2023
Summary
Tuberculosis patients show altered CD8+ T cell profiles, with specific subsets like EM1 and Tc2 cells increasing while others decrease. This indicates impaired T cell maturation and function in active tuberculosis.
Area of Science:
- Immunology
- Cellular Biology
Background:
- Macrophages, Th1, and CD8+ T cells are crucial for controlling tuberculosis (TB).
- Understanding CD8+ T cell subsets is vital for TB diagnostics and treatment.
Purpose of the Study:
- To identify diagnostically significant CD8+ T cell subsets in pulmonary tuberculosis patients.
- To analyze the changes in CD8+ T cell populations during active TB infection.
Main Methods:
- Analyzed peripheral blood from 32 pulmonary TB patients and 31 healthy controls.
- Utilized 10-color flow cytometry to assess CD8+ T cell subsets and markers.
Main Results:
- Reduced frequency of EM4 CD3+CD8+ cells and increased EM1 CD3+CD8+ cells in TB patients.
- Altered CD57 expression on various CD8+ T cell subsets (EM1, EM2, pE1, EM3).
- Increased Tc2 (CCR6-CXCR3-) and decreased Tc1 (CCR6-CXCR3+) cells observed in TB patients.
Conclusions:
- Pulmonary tuberculosis is associated with an abnormal CD3+CD8+ T cell profile.
- These alterations suggest impaired maturation and functional activity of CD8+ T cells in TB.
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