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Related Experiment Videos

Filterability of ACD-stored red cells.

G Galea

    Vox Sanguinis
    |January 1, 1986
    PubMed
    Summary

    Stored red blood cells (erythrocytes) lose their deformability quickly, even within 5 days. Acid citrate dextrose (ACD) is not ideal for maintaining erythrocyte rheological properties during blood storage.

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    Area of Science:

    • Hematology
    • Blood banking
    • Biophysics

    Background:

    • Erythrocyte deformability is crucial for microcirculation.
    • Blood storage can negatively impact erythrocyte function.
    • Assessing rheological changes during storage is important for transfusion efficacy.

    Purpose of the Study:

    • To evaluate the impact of standard blood banking conditions on erythrocyte deformability.
    • To assess the efficacy of Acid Citrate Dextrose (ACD) as a storage medium for maintaining erythrocyte rheological properties.

    Main Methods:

    • Erythrocyte deformability was measured using the Myrenne filtrometer MF4.
    • Blood was stored in ACD for up to 3 weeks under standard blood banking conditions.
    • Filterability studies were conducted at various time points during the storage period.

    Main Results:

    • A significant decrease in erythrocyte filterability was observed as early as day 5 of storage.
    • The reduction in deformability indicates a decline in the rheological quality of stored erythrocytes.
    • These findings suggest that ACD may not be an optimal storage medium for preserving erythrocyte deformability.

    Conclusions:

    • Acid citrate dextrose (ACD) is not a suitable storage medium for maintaining erythrocyte rheological properties.
    • Further research is needed to explore alternative storage media for blood banking.
    • Investigating different storage solutions is essential to mitigate the 'rheological lesion' in stored erythrocytes.

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