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Circadian Gene Variants in Diseases
1Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, 10 000 Zagreb, Croatia.
Genes
|September 28, 2023
Summary
Circadian rhythm genes regulate daily cycles. Variants in these core and secondary circadian genes are linked to diseases like cancer, metabolic disorders, and sleep issues.
Area of Science:
- Genetics
- Chronobiology
- Molecular Biology
Background:
- The circadian rhythm governs 24-hour physiological cycles, including sleep-wake patterns.
- Cellular clocks, driven by protein interactions, regulate individual cell rhythms.
- Core molecular clock proteins (CLOCK-BMAL1 and PER-CRY) form a negative feedback loop.
Purpose of the Study:
- To review existing knowledge on circadian gene variants.
- To explore associations between circadian gene variations and diseases.
- To highlight the role of both main and secondary circadian genes in health.
Main Methods:
- Literature review of studies on circadian gene variants.
- Analysis of associations between genetic variations and disease phenotypes.
- Synthesis of current understanding of molecular clock mechanisms.
Main Results:
- Circadian gene variants are implicated in various pathologies.
- Specific variants in core and secondary circadian genes correlate with increased disease risk.
- Disruptions in the molecular clock can influence susceptibility to tumors, metabolic, cardiovascular, and sleep disorders.
Conclusions:
- Circadian gene variants represent a significant factor in disease development.
- Understanding these genetic associations can inform disease prevention and treatment strategies.
- Further research into circadian genetics is crucial for advancing personalized medicine.
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